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Orbitrap™ Excedion™ Pro Mass Spectrometers
Akselerasi analisis molekul kecil dan multi-omics Anda dengan Orbitrap Excedion MS. Platform HRAM sensitivitas tinggi untuk metabolomik dan biofarmasi
Dapatkan kepastian penuh dalam analisis molekul kecil dan multi-omics pada sampel kompleks. Akselerasi wawasan di bidang metabolomik, metabolisme obat, dan penelitian lingkungan dengan Orbitrap Excedion™ MS, platform high-resolution accurate-mass (HRAM) serbaguna yang memberikan sensitivitas tinggi, rentang dinamis yang diperluas (eDR), dan akurasi massa sub-ppm.
Instrumen ini dirancang fleksibel dan dapat ditingkatkan (upgrade) langsung di laboratorium menjadi Orbitrap Excedion™ Pro MS untuk memperluas kapabilitas penelitian proteomik dan biofarmasi tingkat lanjut, termasuk deteksi massa hingga m/z 12.000 dengan opsi fragmentasi ETD/EThcD yang cepat dan sensitif.
Kapabilitas dan Keunggulan Utama:
Metabolomik Mendalam: Memungkinkan pembuatan profil metabolomik presisi dengan sensitivitas tinggi, eDR, dan performa HRAM. Dilengkapi fitur peralihan polaritas cepat, kapabilitas aliran nano (nano-flow), serta integrasi alur kerja Compound Discoverer untuk cakupan analisis yang luas hingga lipidomik sel tunggal.
Identifikasi Metabolit (MetID) Akurat: Menggabungkan HRAM dan eDR untuk mendeteksi metabolit berkelimpahan rendah (low-abundance) bersama senyawa induknya. Akurasi massa sub-ppm dan alur kerja terintegrasi dengan perangkat lunak Compound Discoverer dan Mass MetaSite memastikan anotasi data yang sangat meyakinkan.
Lingkungan & Keamanan Pangan (EFS): Menghadirkan analisis analitik EFS yang sensitif dengan peningkatan sensitivitas MS1 dan eDR untuk deteksi tingkat jejak (trace-level). Data pemindaian penuh HRAM secara komprehensif mendukung skrining senyawa mencurigakan dan analit tak bertarget (non-target), termasuk PFAS dan kontaminan baru.
Analisis Biofarmasi Spesifik: Edisi BioPharma mendukung analisis melalui mode oligonukleotida khusus dengan kontrol tekanan yang dioptimalkan. Fitur ini memfasilitasi analisis massa utuh, sekuensing, serta karakterisasi kuantitatif mRNA, oligonukleotida, dan spesies terkait ADC.
Ekspansi Proteomik (Edisi Pro): Melalui upgrade ke edisi Pro BioPharma, pengguna dapat memanfaatkan opsi fragmentasi ETD untuk deteksi Asp/IsoAsp, resolusi Leu/Ile, cakupan middle-down yang lebih luas, dan HDX-MS tingkat residu tunggal guna mendukung analisis proteom mendalam, PTM, serta imunopeptidomik.
Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology
| Specifications | |
|---|---|
| Detection Limits | Full Scan: < 1.5 fg reserpine on column MS2: < 1.5 fg reserpine on column SIM: < 0.8 fg reserpine on column |
| Dimensions (D x W x H) | 29.8 x 21 x 27.6 in. (758 x 535 x 703 mm) |
| Dynamic Range | 5 orders of magnitude intrascan dynamic range |
| Fragmentation | Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard. Electron Transfer Dissociation (ETD) for c/z ion fragmentation is factory installed. |
| Green Features | ACT Ecolabel (Platinum) |
| Mass Accuracy | 1-point calibration for <3 ppm RMS drift over at least 4 weeks* Internal lock mass calibration for <1 ppm RMS drift over 24 hours* EASY-IC for <1 ppm RMS drift for at least 5 days* *Under defined conditions |
| Model | Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology |
| Multiplexing | Up to 20 precursor ions per scan |
| Max. Resolution | Up to 480,000 at 200 m/z |
| Type | Orbitrap LC-MS |
| Unit Size | Each |
Orbitrap Excedion Pro BioPharma Mass Spectrometer
| Specifications | |
|---|---|
| Detection Limits | Full Scan: < 1.5 fg reserpine on column MS2: < 1.5 fg reserpine on column SIM: < 0.8 fg reserpine on column |
| Dimensions (D x W x H) | 29.8 x 21 x 27.6 in. (758 x 535 x 703 mm) |
| Dynamic Range | 5 orders of magnitude intrascan dynamic range |
| Fragmentation | Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard. Electron Transfer Dissociation (ETD) for c/z ion fragmentation is option at factory install or field upgrade. |
| Intact Protein Mode | Enhanced performance for larger molecules |
| Mass Accuracy | 1-point calibration for <3 ppm RMS drift over at least 4 weeks* Internal lock mass calibration for <1 ppm RMS drift over 24 hours* EASY-IC for <1 ppm RMS drift for at least 5 days* Mass accuracy, single mass* Internal calibration achieves <0.2 ppm RMS for m/z 262.63612 [MRFA2+] in positive mode Internal calibration achieves <0.2 ppm RMS for m/z 362.96962 [Perfluoroheptanoic acid] in negative mode *Under defined conditions |
| Model | Orbitrap Excedion Pro BioPharma Mass Spectrometer |
| Multiplexing | Up to 20 precursor ions per scan |
| Max. Resolution | Up to 480,000 at 200 m/z |
| Type | Orbitrap LC-MS |
| Unit Size | Each |
EASY-ETD option available at factory install or field upgrade for Orbitrap Excedion Pro Mass Spectrometers.
| Specifications | |
|---|---|
| Fragmentation | Electron Transfer Dissociation (ETD) - Fast and sensitive Electron Transfer Dissociation reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation. |
| Model | EASY-ETD option available at factory install or field upgrade for Orbitrap Excedion Pro Mass Spectrometers. |
| Unit Size | Each |
Orbitrap Excedion Pro Mass Spectrometer for metabolomics, lipidomics, proteomics, and structural biology
| Specifications | |
|---|---|
| Detection Limits | Full Scan: < 1.5 fg reserpine on column MS2: < 1.5 fg reserpine on column SIM: < 0.8 fg reserpine on column |
| Dimensions (D x W x H) | 29.8 x 21 x 27.6 in. (758 x 535 x 703 mm) |
| Dynamic Range | 5 orders of magnitude intrascan dynamic range |
| Fragmentation | Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard. Electron Transfer Dissociation (ETD) for c/z ion fragmentation is optional as a field upgrade. |
| Green Features | ACT Ecolabel (Platinum) |
| Mass Accuracy | 1-point calibration for <3 ppm RMS drift over at least 4 weeks* Internal lock mass calibration for <1 ppm RMS drift over 24 hours* EASY-IC for <1 ppm RMS drift for at least 5 days* *Under defined conditions |
| Model | Orbitrap Excedion Pro Mass Spectrometer for metabolomics, lipidomics, proteomics, and structural biology |
| Multiplexing | Up to 20 precursor ions per scan |
| Max. Resolution | Up to 480,000 at 200 m/z |
| Type | Orbitrap LC-MS |
| Unit Size | Each |
Field upgrade Electron Transfer Dissociation (ETD)
| Specifications | |
|---|---|
| Fragmentation | Fast and sensitive ETD reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation. |
| Model | Field upgrade Electron Transfer Dissociation (ETD) |
| Type | Orbitrap LC-MS |
| Unit Size | Each |